Saturday, June 30, 2012

Hornets select Davis with No. 1 pick in NBA draft

NEWARK, N.J. (AP) ? Anthony Davis hugged his college teammate, hugged his coach, and climbed on stage as the No. 1 pick.

Turns out, that was just the start of Kentucky's party at the NBA draft.

The Wildcats became the first school to have the top two picks and tied a record with six players taken overall Thursday night.

After the New Orleans Hornets made the long-expected selection of Davis, Charlotte followed by taking fellow freshman Michael Kidd-Gilchrist.

Saying he was nervous even though his selection was no surprise, Davis shared an embrace with Kidd-Gilchrist, seated at a nearby table.

"My arm was shaking and my hands were sweaty. Got up and hugged Michael, my best friend, wanted to hug him for a minute," Davis said. "When my name got called, wanted to make sure he stayed close."

He did ? following Davis as the next player to climb up and shake Commissioner David Stern's hand.

"It's crazy," Davis said moments after Kidd-Gilchrist's selection. "Michael is a great player. We have two down and four more to go. Hopefully, all of them will go in the first round."

They didn't, the only disappointment for the Wildcats. They settled for four in the first round and a tie with North Carolina, which won the race to four picks ? all in the top 17 selections.

Harrison Barnes (No. 7, Golden State), Kendall Marshall (No. 13, Phoenix), John Henson (No. 14, Milwaukee) and Tyler Zeller (No. 17, Dallas and later traded to Cleveland) all went between Kidd-Gilchrist and the next Kentucky player, Terrence Jones at No. 18 to Houston.

Otherwise, it was the Wildcats' night.

Kentucky got its fourth first-round pick at No. 29 with Marquis Teague, another freshman, who is headed to Chicago as a possible replacement for the injured Derrick Rose. Doron Lamb went 42nd to Milwaukee, and Darius Miller was 46th to New Orleans.

Only UNLV in 1977 had six players drafted ? but none in the first round.

Kentucky coach John Calipari has been criticized for recruiting "one-and-done" players, they stay the required one year and leave, but he looked thrilled hugging his two stars at the start of the night.

It's been a long time since a school made such an impact at the top of the draft.

UCLA had the Nos. 1 and 3 picks in 1969, when Milwaukee took Kareem Abdul-Jabbar ? then Lew Alcindor ? and Lucius Allen went third to the Seattle SuperSonics.

Davis will begin his pro career in the same city where he ended it with a national title. College basketball's player of the year as a freshman was the Most Outstanding Player of the Final Four despite shooting just 1 for 10 from the field in the championship game, grabbing 16 rebounds and blocking six shots in the victory over Kansas.

Davis slipped on a blue and purple Hornets hat above a conservative gray suit that took no attention away from basketball's most famous eyebrow. Davis even attempted to capitalize on the attention his unibrow gets, trademarking "Fear The Brow" and "Raise The Brow" earlier this month.

On the floor, Davis has the agility of a guard ? and he was one only a few years ago.

The 6-foot-10 Davis averaged 14.2 points, 10.4 rebounds and 4.7 blocks, becoming a dominant defender after growing 7 inches from the start of his junior year of high school.

A season after the Hornets traded longtime star Chris Paul, Davis is ready to be their centerpiece, since playing for the Wildcats means he is already accustomed to plenty of attention.

"Like I said, at Kentucky we had it all the time, especially the six who played, we had the spotlight all the time," Davis said. "I think it really prepared me."

Charlotte, coming off a 7-59 season and the worst winning percentage in NBA history, had been open to moving the No. 2 pick if it found the right deal. Instead, Michael Jordan's team went with Kidd-Gilchrist, whose selection by the Bobcats was loudly cheered, a sharp contrast from the boos Stern received when he came out to announce the picks.

The new Charlotte swingman played in high school at nearby St. Patrick's in Elizabeth, N.J., and fans chanted "MKG! MKG!" as he walked off the stage. Though he and Davis talked before the draft, they didn't discuss the history the Wildcats were about to make.

"No. I was shocked at first," Kidd-Gilchrist said. "I was shocked. But no, we didn't. We didn't at all."

Florida's Bradley Beal went third to Washington, making it three SEC freshman in the first three picks. Cleveland followed with the surprisingly early pick of Syracuse sixth man Dion Waiters at No. 4.

Thomas Robinson of Kansas, who hoped to go second, fell to Sacramento at No. 5. Portland took Weber State's Damian Lillard at No. 6 with its first of two lottery picks, and Barnes was taken seventh by Golden State.

After Washington's Terrence Ross went to Toronto and Connecticut's Andre Drummond to Detroit, the Hornets rounded out the top 10 by taking Duke guard Austin Rivers with a pick they acquired in the Paul trade. Rivers hugged his father, Boston coach Doc Rivers, who came to be with his family instead of with the Celtics, who owned two later first-round picks.

Davis was the only clear-cut pick entering the draft, and there were some early surprises. Players such as Waiters and Ross went higher than expected, while Robinson dropped to the Kings.

"I really didn't know where I was going to end up at, but it is a bit of a surprise," he said, tearing up when talking about his difficult journey that included the deaths of multiple family members in college. "I didn't work out for Sacramento at all, I probably talked to them about once. But I'm here, so I'm meant to be here."

Houston took Jeremy Lamb of Connecticut at No. 12 with its first of three top-20 picks. But the Rockets, who also had the Nos. 16 and 18 picks, were hoping not to use all of them, instead packaging them for an established player after their pursuit of the Lakers' Pau Gasol fell through last year.

The Rockets tabbed Iowa State's Royce White at No. 16, and Terrence Jones two picks later.

Jared Sullinger, once considered a top-10 pick, ended up in a draft free-fall over concerns with his back but was finally taken at No. 21 by Boston. The Celtics followed with Fab Melo of Syracuse, giving them two potential replacements if Kevin Garnett doesn't return.

The NBA champion Miami Heat took forward Arnett Moultrie of Mississippi State at No. 27 with their first-round pick, but traded his rights to Philadelphia for the rights to LSU center Justin Hamilton and a future first-round pick.

___

Follow Brian Mahoney on Twitter: http://www.twitter.com/Briancmahoney

Source: http://news.yahoo.com/hornets-select-davis-no-1-pick-nba-draft-234120493--spt.html

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Planners say 'not so fast' to wind energy in northeastern Vermont

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Meribel Olympic Sports Centre The Skiing Blog

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Friday, June 29, 2012

Google Bows To Apple: Chrome On iOS Will Use Apple?s Slow UIWebView To Render Web Pages

chromelogoGoogle is launching Chrome for iOS today. Many pundits assumed that Google was holding back Chrome from iOS because it couldn't use its own rendering engine, however, Google just told us that Chrome will actually use the same rendering engine that Apple makes available to every other third-party developer on iOS.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/H518WLuNYAo/

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Karadzic acquitted of one count of genocide

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Thursday, June 28, 2012

Branding Your Company on Instagram - GetUWired

At GetUWired we strive to stay updated on all things marketing! Now I?m sure you?ve heard us mention a time or two about marketing on sites such as Instagram but now we have proof! Will you believe it if you see it with your own eyes? I certainly hope so!

Instagram has proved itself to be marketing friendly, if you know how to market. The new forms of marketing popping up aren?t just a culture favorite. Sites like Instagram and Pinterest offer their users and companies a more personal aspect of marketing. Still not sure about it? Check out this blog we found on Hubspot. After seeing these results, you won?t want to miss out on this marketing opportunity!

The 10 Best-Branded Companies on Instagram

Earlier this year, we profiled five brands that have each built themselves a solid marketing presence on Instagram, the popular photo editing and sharing social network so often linked to Twitter and Facebook updates. We?ve also stressed the why and how of using Instagram for marketing, citing the increasing importance of mobile marketing, and how that should be playing into the strategies and tactics of your social media marketing.

Now, I?m sure most of you know that social media is important. I?m also confident that many of you know some basic strategies. But let?s talk about the Earlybird-filtered big picture: when it comes to presenting your brand on social media, your reputation and brand image is only as strong and complete as your most recent update. If your content is off-brand, your image will come across as confused, incomplete, or just plain wrong. That?s not to say you should be dropping nothing but explicitly on-product tweets, but to say that your content, be it original or shared, should always carry within it some sort of a representation or affirmation of your brand?s identity in some way. In fact, a Facebook study just recently confirmed this very philosophy!

An interesting way to explore this constant depiction of brand values and traits is through?you guessed it!?Instagram photos posted by brands. Check out the following images and learn how these ten companies completely nailed the representation of their respective brands.
Annie?s Homegrown

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Annie?s Homegrown has done an excellent job of asserting its brand identity as an all-natural, organic, and healthy provider of foods Americans love, from macaroni and cheese to frozen pizza to fruit-flavored gummy snacks. The brand understands how important these qualities have become to its target demographic, so its Twitter strategy is based upon sharing product news, tasty-sounding recipes, and Instagram photos. This shot of a wooden version of Annie?s logo keeping guard over a small vegetable garden incorporates several important parts of Annie?s brand identity. It takes the brand?s logo, already cute and loveable, and places him directly amidst the action of the brand?s foundation. Additionally, the garden is small, and looks to be on a residential street instead of a factory, implying that Annie?s ingredients are not only natural and organic but also as homegrown as the brand name implies.
Billboard

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Billboard is, like many other publications that originated in print, evolving its strategy to mesh with the era of real-time social content. On Twitter, Billboard uses Instagram to capture photos of the stars gracing its pages and share their presence within its brand in real time. The Billboard brand is based on its knowledge of who?s on top in the music industry, and its revelations of music previews, exclusive photographs, and breaking news in the music industry. Twitter is an excellent platform for Billboard to explore these real-time aspects of its brand identity, and Instagram allows for this exploration to turn into proof ? Billboard can reveal its latest associations in more casual, semi-candid photographs, which make the stars?and thus, Billboard?appear more real and genuine.

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Brisk has gone through quite the evolution as a brand. Named after an archaic definition of the word ?brisk? that means ?tangy,? the drink has become Lipton Tea?s attempt to compete with various other popular canned tea drinks in today?s beverage-to-go market. This Instagram photo of a hand just about to pop the tab on a can of Brisk, coupled with a caption referring to the can as an alarm clock, serves two brand-representation purposes: it cues the viewer to imagine the scene playing out, watching the hand open the can and hearing the satisfying popping sound as the task is completed. The filter of the photo is one of Instagram?s many filters meant to call-back to older photos, just as Brisk?s name recalls an earlier definition of a flavor. This makes the brand seem both long-lasting and nostalgic, yet entirely modern due to the update?s home in social media.
The Boston Celtics

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

The Boston Celtics are quite the social basketball team. Their Twitter presence is huge, from the individual players? accounts to the strong social media strategy utilized to market the Celtics as more than just a basketball team, but also a brand built on the history of Boston, the luck of the Irish, and the joy of the game. They?re a team that builds its reputation on hard work and fast-paced play. This Instagram photo, sent out in a tweet just before the start of a game, captures a real-time moment that likely passed without notice, but displays the team?s togetherness, dedication to the game, uniformity, and excitement to go play, all in one shot. It also assists with the Celtics? down-to-earth reputation in delivering a photo that is close-up, placing the fans? viewpoints on par with the players, and low to the ground, literally implying that the team is down-to-earth and willing to put their noses to the grindstone to get to work.
Coach

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Coach can sum up its brand identity in three words: classy, trendy, and luxurious. Seeing a Coach logo on a bag instantly raises the bag?s (and carrier?s) social capital, and the price tags attached to Coach bags are more than enough evidence to point toward their earned status as a luxury brand. In Coach?s Twitter feed, ample evidence of these three points are pronounced, but none are as pronounced as in its Instagram account. In this image, Coach divides a purse into three smaller photographs, all muted by a filter to suggest the classiness of the bag, despite its loud, unmuted color. The logo is present in two of the photographs, with the third zeroing in on the handcrafted detail of the bag, reinforcing Coach?s high-quality reputation by showing consumers the details in a setting more causal than a photography shoot, and more personal than a busy store.
Forever21

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Forever21 is a clothing brand dedicated to affordable, trendy fashion. Despite its smaller price tags and distinctly non-couture reputation, from its name, Forever21 indicates that with its brand, it?s attempting to emulate a timeless feeling, through which clothing buyers can remain rooted in a particular time or age. In this Instagram shot, sent out over Forever21?s official Twitter account to announce some new arrivals to its stores, the recently-declared-back-in leopard print trend is paired with timeless fashion staples, and then sent through a nostalgia-inducing filter that ages the photograph back to the last time leopard print was in.
PepsiMAX

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

PepsiMAX is one of the newest product launches of megabrand Pepsi, and can be classified as Pepsi?s attempt to bridge the energy drink and ?healthy? soda categories for sales. The brand identity pushed for PepsiMAX is that of something fresh, modern, and exciting, while also familiar to the trusted Pepsi brand consumers know and love. The Twitter feed for PepsiMAX, separate from its parent brand, serves to illustrate these seemingly paradoxical qualities, especially through its liberal use of Instagram. In this photo, we see an over-saturated image of a PepsiMAX can and a billboard of its ad campaign, indicating the real-time freshness of the drink and the update alike, paired with a foosball table, an activity that has been around for years that requires focus and one-on-one competition. PepsiMAX asks us to recall the in-the-moment feeling of playing a fresh round of a game we?ve all known for years, pairing that memory with its brand offering.
Puma

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Puma is a footwear brand with attitude. Originally choosing to instill the quickness, agility, and hunting prowess of a puma cat with its footwear, this Instagram photograph suggests a far more laid back image. With the old photograph-toned filter, the presence of a pair of shoes on a person and a pair of shoes shed from a person, as well as the leisurely pace of the activity portrayed, it shows consumers that Puma shoes don?t only allow you to speed past every opportunity, but they also get you to places you can enjoy with others, and remember for a long time. While Twitter is fast-paced, filled with customer service interactions, product announcements, and other news, Puma?s Instagram account is a refreshing change, reminding users that Puma knows its product isn?t just about the journey; it?s also about the destination.
Sharpie

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Sharpie is an odd presence on Twitter. Its flagship product, permanent markers, is hardly something that seems easy to market on Twitter at first glance; however, the acute focus on artistic freedom and expression that Sharpie integrates into its brand makes it one of the most successful social branding companies on Instagram. Many of its Instagram snapshots, each posted to Twitter and enjoyed by many followers, does not feature the markers themselves, but rather their ink as applied to some sort of canvas by unique individuals. In this particular composition, for example, Sharpie has brought alive an artist?s passion for music, through the quick, black-and-white illustration of old-school headphones. Choosing headphones over earbuds indicates a preference for the classic, timeless instruments that have a permanent place upon the scene, which are exactly what Sharpie markers and their permanent inks are intended to be.
Starbucks

Instagram for small business, Small business branding, small business social media branding, Small Business Social Media Marketing, social media branding, Social Media Marketing

Starbucks got a mention in our last Instagram post, too, and it?s no wonder why. The coffee retailer is almost definitely the brand making the absolute most out of its Instagram-centric social media strategy. Starbucks strives to be seen as a local-friendly, socially conscious coffee shop that happens to have, oh, a few locations, rather than just another large corporate chain. In this particular image, we see bags of beans, for sale in the shops, that subtly boast the Starbucks logo, and a tray of samples of this coffee, conceivably headed for the counter of the tweeter?s local Starbucks location to be handed out to individuals. The coffee is unaltered, and the background is dimmed to black, allowing Starbucks to assert that when it comes to its brand, two things matter: the coffee and the customers? opinions.

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Planned Google tablet to rival Amazon: Asustek exec

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General Introduction of Green Tea

[unable to retrieve full-text content]According to a survey released by the United States Department of Agriculture in 2007, the mean content of flavonoids in a cup of green tea is higher than that in the same volume of other food and drink items that are ...

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Friday, June 22, 2012

Lovie's got company on hot seat

June 21, 2012, 2:06 pm

Missing the playoffs four of the past five years has understandably put Bears head coach Lovie Smith on whatever kind of job hot seat the NFL has. Jerry Angelo took the fall for some of the missteps of the post-Super Bowl XLI issues but a new general manager and new chairman are not wedded to Smith.
?
And if two remaining contract years worth $11 million were reason to give Smith the 2012 season, one year won?t be after this.
?
But Smith is far from the only NFC North coach around whom a serious degree of pressure is building.
?
The Green Bay Packers won a Super Bowl in 2010 but were a first-game playoff elimination last season. Mike McCarthy has a team that is established as Super Bowl-worthy and another stumble in 2012 will likely start questions about McCarthy?s stewardship.
?
Leslie Frazier took over a disaster in Minnesota but has now been given a starting quarterback, starting left tackle and help in the secondary in the past two draft first rounds. GM Rick Spielman may not be willing to consider trading unhappy wide receiver Percy Harvin but he will assuredly be considering options if the Vikings put up another 3-13 season.
?
But the most intriguing situation is over in Detroit. Jim Schwartz ostensibly has reversed the abysmal slide of the Lions. But he also has a roster with a No.1-overall pick at quarterback and two No. 2-overalls (Ndamukong Suh, Calvin Johnson) to go with a franchise-tagged defensive end (Cliff Avril).
?
The Lions likely do not qualify for the playoffs last season without Jay Cutler fracturing his thumb. And GM Martin Mayhew told Anwar Richardson over at Mlive.com that the Lions expect to win a Super Bowl ?eventually.?
?
Mayhew says he is a believer in continuity, speaking of players, coaches and organization, but the Lions have not won a playoff game since Mayhew came in 2009 and anything less than at least a playoff win this season can be considered nothing less than a huge step backwards with a team virtually in its prime.
?
The Michael Jordan Chicago Bulls could see the mountain top with Doug Collins as head coach. But when they couldn?t get to that level, a change was made to Phil Jackson from a pretty successful coach.
?
If Schwartz cannot end the enabling of character discipline issues that have made the Lions an object of ridicule, he may be called to accountability for underachieving talent sooner rather than later.

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Video: First Read Minute

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Improve the Exterior Appearance of Your Home

If the outside of your home has fallen into disrepair, you can make improvements that are easy and inexpensive. For the resale value of your home, the exterior appearance is incredibly important. Some potential home buyers will not stop to look at a home whose exterior is worn out and unattractive.

Use landscaping to highlight specific areas of your home. Trim bushes, trees and shrubs to make sure your home is visible beyond these plants. If you have a front porch or steps that lead to the front door, use potted plants to increase the charm of your home. Use plants or stepping stones to enhance the walkway and plant some perennials so you can enjoy bright, colorful flowers.

Remove excess dirt, chipping paint, spider webs and debris by power washing the entire exterior of your home. You can rent a high powered pressure washer to give your house a clean appearance.

These washers are available from your local hardware store and are relatively inexpensive. Remember to clean the entire exterior of your home, including your roof, deck and porches while you have the equipment.

Painting your front door can give your home a whole new look. Avoid painting your door a color that makes it blend into the rest of the home. Choose an attractive contrasting color for the best results. If you are unsure of a good color, compare your exterior paint color with the possible colors for your door with swatches. Some hardware stores organize their paint swatches so that coordinating colors are close to each other. You can also drive around your neighborhood to get ideas for paint colors.

Consider installing replacement windows.? Not only will you increase the value of your home and improve it's appearance but you will also save a great deal of money on your heating and cooling bills.

Using solar lights is a great way to highlight pathways in your front and back yards.

Solar lights are inexpensive, easy to install and do not require electricity. They soak up the sun all day and use the power from the sun to stay bright all night. Solar lighting is available in a wide variety of styles to enhance the appearance of any type of landscaping.

Loose roof tiles, gutter and trim make your home look old and in need of repair. You can easily replace or repair these problems yourself at a minimal cost. Make sure to match shingles and tiles exactly for a uniform look. Use high quality construction nails to repair loose trim and hanging gutters. You should also take the time to clean your gutters. Even though you cannot see what is inside your gutters, debris can be quite dangerous.

If you have not done much gardening lately, now is a great time to spruce up your flower beds. Use a small rake to remove weeds, add fertilizer and replant flowers and plants that no longer look healthy. Brighten up the flower bed with new mulch, rocks or wood chips.

Updating the exterior of your home is possible with a lot of hard work and a little bit of expense. From painting to gardening, you can make improvements by yourself. These improvements will increase the curb appeal of your home.

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Charlie Sheen to play prez in 'Machete' sequel

Mario Anzuoni / Reuters

By Bruna Nessif, E! Online

Can you imagine a country run by Charlie Sheen??Well, now you don't have to!?Director Robert Rodriguez announced via Twitter that he has cast the former "Two and a Half Men" star as the president of the United States for his upcoming film, "Machete Kills."

READ: American Idol's Jessica Sanchez in talks to join "Glee!"

"I just cast Charlie Sheen in #machetekills as the President of the United States! Who better? More soon...?http://yfrog.com/h38lgnuj," Rodriguez tweeted along with a photo of himself and our future onscreen commander in chief.

GALLERY: Charlie Sheen: Quote machine?

And, of course, Sheen forwarded the news to his own Twitter family with the proper lead-in, "My Fellow Americans!" He's got this role down pat.The film, which also stars Michelle Rodriguez, Amber Heard and Mel Gibson, is a sequel to the 2010 film ?"Machete" and is slated for a 2013 release.?

Does this casting make you want to see the movie? Tell us on Facebook.

Related content:

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Saturday, June 16, 2012

Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target

Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target [ Back to EurekAlert! ] Public release date: 15-Jun-2012
[ | E-mail | Share Share ]

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research

PHILADELPHIA A substantial proportion of NK/T-cell lymphomas harbor Janus Kinase 3 gene mutations. Patients with these lymphomas might benefit from treatment with a Janus Kinase inhibitor according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

"Very little was known about the genetic and molecular defects causing NK/T-cell lymphoma before we started this work," said Bin Tean Teh, M.D., Ph.D., director of the National Cancer Center Singapore-Van Andel Research Institute Translational Research Laboratory at the NCCS, and professor at the Duke-NUS Graduate Medical School in Singapore. "There is no effective treatment and this type of cancer carries an extremely poor prognosis.

"It is tremendously rewarding to have identified genetic mutations that appear to have an important role in driving the cancer in a considerable fraction of cases. Moreover, we are excited that there is a drug already in phase III trials for the treatment of rheumatoid arthritis that targets the mutant protein. We are in the process of planning a clinical trial to study whether this drug benefits NK/T-cell lymphoma patients," said Teh.

NK/T-cell lymphoma is a very aggressive form of lymphoma. It is particularly prevalent in Asia.

"Many years ago, I and a colleague came to the Van Andel Research Institute in Grand Rapids, Mich.," said Teh. "My colleague unfortunately developed NK/T-cell lymphoma and passed away. It was the only case of this cancer ever diagnosed in Grand Rapids. As this illustrates, it is a relatively rare subtype of lymphoma in the United States, but it is responsible for the deaths of a large number of people in Asia, in particular in China and Korea. It accounts for almost half of all T-cell lymphomas in some parts of Asia.

"The passing of my colleague, whom I was very close to, was the reason that I started studying NK/T-cell lymphoma. It has been a complicated puzzle, but I feel that we have pieced together enough that we will have an impact on a large number of patients with this disease."

To identify genetic mutations that might have a functional consequence, Teh and his colleagues sequenced all the genes in NK/T-cell lymphoma cells from four patients. In addition to mutations in genes known to be associated with cancer, they detected mutations in the Janus Kinase 3 (JAK3) gene in the cancer cells from half of the patients. The researchers conducted follow-up sequencing of NK/T-cell lymphoma cells from an additional 65 patients and identified JAK3 mutations in 23 of those patients.

The mutations enabled NK/T-cell lymphoma cell lines to grow in culture in the absence of the normally essential growth factor IL-2. This meant that the mutations caused dysregulated activation of JAK3, and suggested that JAK3 might be a good drug target.

Consistent with this idea, a JAK inhibitor that is currently being assessed in phase III clinical trials as a treatment for rheumatoid arthritis killed cultured NK/T-cell lymphoma cell lines by a process known as apoptosis.

"We are currently putting together a proposal to test JAK inhibitors as a treatment for NK/T-cell lymphoma with JAK3 mutations," said Teh. "I am hopeful that we might have found a molecular target for the treatment of a least some patients with this otherwise fatal disease."

###

Follow the AACR on Twitter: @aacr #aacr
Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the AACR

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR's membership includes 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of individual and team science grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.

For more information about the AACR, visit www.AACR.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target [ Back to EurekAlert! ] Public release date: 15-Jun-2012
[ | E-mail | Share Share ]

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research

PHILADELPHIA A substantial proportion of NK/T-cell lymphomas harbor Janus Kinase 3 gene mutations. Patients with these lymphomas might benefit from treatment with a Janus Kinase inhibitor according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

"Very little was known about the genetic and molecular defects causing NK/T-cell lymphoma before we started this work," said Bin Tean Teh, M.D., Ph.D., director of the National Cancer Center Singapore-Van Andel Research Institute Translational Research Laboratory at the NCCS, and professor at the Duke-NUS Graduate Medical School in Singapore. "There is no effective treatment and this type of cancer carries an extremely poor prognosis.

"It is tremendously rewarding to have identified genetic mutations that appear to have an important role in driving the cancer in a considerable fraction of cases. Moreover, we are excited that there is a drug already in phase III trials for the treatment of rheumatoid arthritis that targets the mutant protein. We are in the process of planning a clinical trial to study whether this drug benefits NK/T-cell lymphoma patients," said Teh.

NK/T-cell lymphoma is a very aggressive form of lymphoma. It is particularly prevalent in Asia.

"Many years ago, I and a colleague came to the Van Andel Research Institute in Grand Rapids, Mich.," said Teh. "My colleague unfortunately developed NK/T-cell lymphoma and passed away. It was the only case of this cancer ever diagnosed in Grand Rapids. As this illustrates, it is a relatively rare subtype of lymphoma in the United States, but it is responsible for the deaths of a large number of people in Asia, in particular in China and Korea. It accounts for almost half of all T-cell lymphomas in some parts of Asia.

"The passing of my colleague, whom I was very close to, was the reason that I started studying NK/T-cell lymphoma. It has been a complicated puzzle, but I feel that we have pieced together enough that we will have an impact on a large number of patients with this disease."

To identify genetic mutations that might have a functional consequence, Teh and his colleagues sequenced all the genes in NK/T-cell lymphoma cells from four patients. In addition to mutations in genes known to be associated with cancer, they detected mutations in the Janus Kinase 3 (JAK3) gene in the cancer cells from half of the patients. The researchers conducted follow-up sequencing of NK/T-cell lymphoma cells from an additional 65 patients and identified JAK3 mutations in 23 of those patients.

The mutations enabled NK/T-cell lymphoma cell lines to grow in culture in the absence of the normally essential growth factor IL-2. This meant that the mutations caused dysregulated activation of JAK3, and suggested that JAK3 might be a good drug target.

Consistent with this idea, a JAK inhibitor that is currently being assessed in phase III clinical trials as a treatment for rheumatoid arthritis killed cultured NK/T-cell lymphoma cell lines by a process known as apoptosis.

"We are currently putting together a proposal to test JAK inhibitors as a treatment for NK/T-cell lymphoma with JAK3 mutations," said Teh. "I am hopeful that we might have found a molecular target for the treatment of a least some patients with this otherwise fatal disease."

###

Follow the AACR on Twitter: @aacr #aacr
Follow the AACR on Facebook: http://www.facebook.com/aacr.org

About the AACR

Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR's membership includes 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the Scientific Partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of individual and team science grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.

For more information about the AACR, visit www.AACR.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Three U.S. crews win trials, qualify for London Olympics

WEST WINDSOR, N.J. (AP) -- The United States rowing squad for the London Games has been completed after three crews won finals at the national Olympic trials.

Ken Jurkowski easily won the men's single sculls by nearly two boat lengths to qualify for his second straight summer games.

Sara Hendershot and Sarah Zelenka, part of the foursome that won gold at the 2011 world championships in Bled, Slovenia, rallied to beat five-time national team members Jamie Redman and Amanda Polk in the women's pair event.

Silas Stafford and Tom Peszek will represent the U.S. in the men's pair after winning their trial on Mercer Lake in West Windsor, N.J.

Copyright 2012 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

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China Sends 3 Astronauts, Including a Woman, Into Space

[unable to retrieve full-text content]The three Chinese astronauts are expected to complete the country?s first manned space docking mission, an important step in Beijing?s ambitious plan to build a space station by 2020.

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Obama interrupted during immigration remarks

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Sunday, June 10, 2012

Facebook shares fall for third straight week

By Benjamin Pimentel, MarketWatch

SAN FRANCISCO (MarketWatch) ? Shares of Facebook Inc. closed with a solid gain Friday, but it wasn?t enough to keep the stock from falling for a third straight week.

Facebook?s /quotes/zigman/9962609/quotes/nls/fb FB +3.00% ?stock traded up 3% to close at $27.10, and briefly was poised to erase the week?s losses. But the stock ended the week down 2.2%.

Jaffe: Lessons from Facebook's IPO

Dig into the theories and conjecture about the deeper meaning of Facebook's embarrassing performance after the initial public offering, and you can at least gain some insight into the market and investor behavior, Chuck Jaffe reports.

The shares have dropped 29% from the social-media service?s initial public offering price of $38, and have yet to end a week in the green. Read story on Facebook and shrinking social-stock valuations.

But the stock?s weekly rate of decline has eased.

The stock shed $6.32, or almost 17%, in its first full week of trading. It then gave up $4.19, or 13%, last week. Facebook slid 62 cents this week.

?The risk return for shorts has probably diminished at this point,? JMP Securities analyst Mark Harding said in a phone interview.

?We?ll probably see some kind of bottoming out and reaching a level where people can get their hands around valuation,? he added.

In fact, Facebook got a lift Friday from a comScore blog post, which said data to be released next week shows that Facebook ads are more effective than investors think. Read MarketWatch First Take on comScore's Facebook data.

Facebook has been hit with negative reports on the effectiveness of its ads, highlighted by the decision of General Motors /quotes/zigman/1466682/quotes/nls/gm GM +0.92% ?to stop buying advertising on the site.

Facebook CEO Mark Zuckerberg

?People are feeling a bit more encouraged about it,? Harding said, referring to the expected data from comScore. ?If we have some data points on the effectiveness of the ads, that would counteract some of the more negative news.?

In fact, he said, word of the upbeat comScore report turned out to be good news for other social-media stocks.

Shares of Yelp Inc. /quotes/zigman/9021597/quotes/nls/yelp YELP +12.10% , LinkedIn Inc. /quotes/zigman/5131883/quotes/nls/lnkd LNKD +2.26% ?, Zynga Inc. /quotes/zigman/7212269/quotes/nls/grpn GRPN +1.32% ?and Groupon Inc. /quotes/zigman/7212269/quotes/nls/grpn GRPN +1.32% ? also posted gains on Friday.

Facebook?s stock has struggled ever since the company?s controversial IPO. On Friday, CNBC reported that UBS AG /quotes/zigman/411392/quotes/nls/ubs UBS -0.51% ?plans to sue Nasdaq OMX Group Inc. /quotes/zigman/86035/quotes/nls/ndaq NDAQ +0.05% ?over losses incurred from glitches during Facebook?s trading debut.

On Friday, Facebook rolled out its App Center where users can access social apps, which included features for downloading apps to mobile devices.

/quotes/zigman/9962609/quotes/nls/fb

US : U.S.: Nasdaq

Volume: 38.00M

June 8, 2012 4:00p

/quotes/zigman/1466682/quotes/nls/gm

US : U.S.: NYSE

Volume: 4.26M

June 8, 2012 4:08p

Rev. per Employee

$733,531

/quotes/zigman/9021597/quotes/nls/yelp

US : U.S.: NYSE

Volume: 1.13M

June 8, 2012 4:07p

/quotes/zigman/5131883/quotes/nls/lnkd

US : U.S.: NYSE

Volume: 3.25M

June 8, 2012 4:07p

Rev. per Employee

$291,452

/quotes/zigman/7212269/quotes/nls/grpn

US : U.S.: Nasdaq

Volume: 6.37M

June 8, 2012 4:00p

Rev. per Employee

$140,391

/quotes/zigman/7212269/quotes/nls/grpn

US : U.S.: Nasdaq

Volume: 6.37M

June 8, 2012 4:00p

Rev. per Employee

$140,391

/quotes/zigman/411392/quotes/nls/ubs

US : U.S.: NYSE

Volume: 3.59M

June 8, 2012 4:08p

Rev. per Employee

$716,539

/quotes/zigman/86035/quotes/nls/ndaq

US : U.S.: Nasdaq

Volume: 2.76M

June 8, 2012 4:00p

Benjamin Pimentel is a MarketWatch reporter based in San Francisco.

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